This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sequeira, J. F. Articles by Hughes, G. R.V. Search for Related Content PubMed PubMed Citation Articles by Sequeira, J. F. Articles by Hughes, G. R.V. Social Bookmarking                         What's this?

Allergic Disorders in Systemic Lupus Erythematosus

Lupus Arthritis Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SEl 7EH, UK

Dajana Cesic

Lupus Arthritis Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SEl 7EH, UK

Gokhan Keser

Lupus Arthritis Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SEl 7EH, UK

Mirjana Bukelica

Lupus Arthritis Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SEl 7EH, UK

Sotirios Karanagnostis

Lupus Arthritis Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SEl 7EH, UK

Munther A. Khamashta

Lupus Arthritis Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SEl 7EH, UK

Graham R.V. Hughes

Lupus Arthritis Research Unit, The Rayne Institute, St. Thomas' Hospital, London, SEl 7EH, UK

Allergic disorders commonly occur in patients with systemic lupus erythematosus (SLE) and allergies to some drugs may occasionally be related to disease flares.

We evaluated the prevalence of several types of allergy in 132 patients with SLE and their families and compared the SLE patients with a control group of 66 patients with non-lupus disorders. Total IgE levels were tested in 117 SLE patients and 61 controls.

Eighty-three of the 132 SLE patients (63 %) had a history of at least one type of allergic disorder. This prevalence was significantly higher (P < 0.0001) than that of the control group (20 of 66 controls). The prevalence of drug allergy (38 % vs. 17 %; P < 0.005), skin allergy (36 % vs. 17 %; P < 0.01) and insect allergy (14 % vs. 2 %; P < 0.02) were significantly higher in SLE patients when compared with controls. Family members of SLE patients had an increased prevalence of at least one type of allergy (55 % vs. 24 %; P < 0.0001), allergic rhinitis (30 % vs. 14 %; P < 0.02), asthma (25 % vs. 9 % P < 0.02), and both rhinitis or asthma (44 % vs. 20 %; P 0.002). The presence of allergy both in the patient and in the family was more frequent in SLE patients than controls (42 '10 vs. 15 %; P < 0.001). We found no differences in total IgE levels between the two groups.

Drug, skin and insect allergies were particularly frequent in SLE patients. We also found a high prevalence of rhinitis and asthma in their families.

Key Words: Allergy • Rhinitis • Asthma • Drug allergy • SLE

Lupus, Vol. 2, No. 3, 187-191 (1993)
DOI: 10.1177/096120339300200311


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				P. F. K. Yong, L. Aslam, M. Y. Karim, and M. A. Khamashta Management of hypogammaglobulinaemia occurring in patients with systemic lupus erythematosus Rheumatology, September 1, 2008; 47(9): 1400 - 1405. [Abstract] [Full Text] [PDF]

				I. Sekigawa, T. Yoshiike, N. Iida, H. Hashimoto, and H. Ogawa Two cases of atopic dermatitis associated with autoimmune abnormalities Rheumatology, January 1, 2003; 42(1): 184 - 185. [Full Text] [PDF]

				I Sekigawa, T Yoshiike, N Iida, H Hashimoto, and H Ogawa Allergic disorders in systemic lupus erythematosus: prevalence and family history Lupus, July 1, 2002; 11(7): 426 - 429. [Abstract] [PDF]

				S A Lander, D J Wallace, and M H Weisman Celecoxib for systemic lupus erythematosus: case series and literature review of the use of NSAIDs in SLE Lupus, June 1, 2002; 11(6): 340 - 347. [Abstract] [PDF]

				S Morton, B Palmer, K Muir, and R J Powell IgE and non-IgE mediated allergic disorders in systemic lupus erythematosus Ann Rheum Dis, November 1, 1998; 57(11): 660 - 663. [Abstract] [Full Text]

				D D'Cruz Vasculitis in systemic lupus erythematosus Lupus, May 1, 1998; 7(4): 270 - 274. [Abstract] [PDF]