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Lupus, Vol. 2, No. 4, 213-220 (1993)
DOI: 10.1177/096120339300200402

Reviews

Review: Role of Transforming Growth Factor Beta (TGFß) in Systemic Autoimmunity

Gina Del Giudice

The Hospital for Special Surgery, The New York Hospital-Cornell Medical Center, New York, USA

Mary K. Crow

The Hospital for Special Surgery, The New York Hospital-Cornell Medical Center, New York, USA

Transforming growth factor (TGFß) is a multifunctional cytokine with proinflammatory as well as immunosuppressive activities. A regulatory role for TGFß has been suggested in investigations of several experimental and spontaneous models of pathological autoreactivity. It is suggested that many of the functional effects of TGFß parallel the major immune system abnormalities seen in SLE.

Key Words: TGFß • SLE • Immunomodulation • Autoimmunity • Tissue repair


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