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Lupus
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Lymphocyte Subsets in a Large Cohort of Patients with Systemic Lupus Erythematosus

Feza Erkeller-Yüksel

Department of Immunology & Rheumatology Research, University College and Middlesex School of Medicine, London

Frank Hulstaart

Becton Dickinson, ICS, Europe

Irene Hannet

Becton Dickinson, ICS, Europe

David Isenberg

Department of Immunology & Rheumatology Research, University College and Middlesex School of Medicine, London

Peter Lydyard

Department of Immunology & Rheumatology Research, University College and Middlesex School of Medicine, London

In search of markers of disease activity in patients with SLE we have investigated blood lymphocyte subsets from a large cohort of patient. Seventy-one patients were studied using a well-defined panel of fluorescent monoclonal antibodies which recognize the major T, B and NK lymphocyte subsets and activated cells. Flow cytometry was used with standard automated software.

Overall, SLE patients were lymphopenic. The proportion of activated T cells was increased and NK cells were decreased in both proportion and absolute numbers (P < 0.001). This decrease was more pronounced in the more active patients.

None of the T cell activation markers was shown to distinguish different degrees of disease activity. However, the percentage of NK cells was significantly reduced in active disease states (P < 0.01). Decreased numbers of NK cells could potentially reduce the resistance of SLE patients to infectious organisms.

Key Words: Lymphocyte subsets • NK cells • Systemic lupus erythematosus

Lupus, Vol. 2, No. 4, 227-231 (1993)
DOI: 10.1177/096120339300200404
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