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Relationship of IL-2, IL-2R (CD25+), Soluble IL-2R and IL-4 with Disease Activity in SLE Patients

Unit of Rheumatology, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, 14004 Cordoba, Spain

Miriam Marubayashi

Unit of Immunology, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, 14004 Cordoba, Spain

Consuelo Ortega

Unit of Immunology, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, 14004 Cordoba, Spain

Nieves Fernandez-Arcas

Unit of Immunology, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, 14004 Cordoba, Spain

Francisco Garcia-Cozar

Unit of Immunology, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, 14004 Cordoba, Spain

Jose Pena

Unit of Immunology, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, 14004 Cordoba, Spain

Pedro Sanchez-Guijo

Unit of Internal Medicine, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, 14004 Cordoba, Spain

Manuel Santamaria

Unit of Immunology, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, 14004 Cordoba, Spain

The plasma levels of interleukin-4 (IL-4), interleukin-2 (IL-2), soluble receptor of IL-2 (IL-2R) and T cell expression of IL-2 receptor chain (CD25⁺) were determined in an attempt to relate these parameters with disease activity in systemic lupus erythematosus (SLE). IL-4, IL-2 and sIL-2R plasma levels of SLE patients were significantly higher than those of the control group (P<0.05) while CD25⁺ expression was similar in both groups. Only sIL-2R levels were significantly higher (P<0.05) in active than in inactive patients.

Key Words: Cytokines • Autoimmune disease • Lupus • Immunossupression

Lupus, Vol. 2, No. 4, 257-260 (1993)
DOI: 10.1177/096120339300200409


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