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Major Histocompatibility Complex Genes and Susceptibility to Systemic Lupus Erythematosus in Northern India

Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi-29, India

Ira Pande

Clinical Immunology Unit, Department of Medicine, All India Institute of Medical Sciences, New Delhi-29, India

Veena Taneja

Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi-29, India

S.S. Uppal

Clinical Immunology Unit, Department of Medicine, All India Institute of Medical Sciences, New Delhi-29, India

S.P. Saxena

Clinical Immunology Unit, Department of Medicine, All India Institute of Medical Sciences, New Delhi-29, India

A. Kumar

Clinical Immunology Unit, Department of Medicine, All India Institute of Medical Sciences, New Delhi-29, India

A.N. Malaviya

Clinical Immunology Unit, Department of Medicine, All India Institute of Medical Sciences, New Delhi-29, India

Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.

Key Words: Major histocompatibility complex (MHC) • SLE • Asian Indians

Lupus, Vol. 2, No. 5, 313-314 (1993)
DOI: 10.1177/096120339300200506


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