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Pulmonary Arterial Hypertension Responsive to Immunosuppressive Therapy in Systemic Lupus Erythematosus

Istituto di I Clinica Medica, University of Rome 'La Sapienza', Policlinico Umberto I, Andrea Cesalpino Foundation, Rome, Italy

Marcello Giordano

Istituto di I Clinica Medica, University of Rome 'La Sapienza', Policlinico Umberto I, Andrea Cesalpino Foundation, Rome, Italy

Paolo De Marzio

Istituto di I Clinica Medica, University of Rome 'La Sapienza', Policlinico Umberto I, Andrea Cesalpino Foundation, Rome, Italy

Roberta Priori

Istituto di I Clinica Medica, University of Rome 'La Sapienza', Policlinico Umberto I, Andrea Cesalpino Foundation, Rome, Italy

Alessandro Sgreccia

Istituto di I Clinica Medica, University of Rome 'La Sapienza', Policlinico Umberto I, Andrea Cesalpino Foundation, Rome, Italy

Guido Valesini

Istituto di I Clinica Medica, University of Rome 'La Sapienza', Policlinico Umberto I, Andrea Cesalpino Foundation, Rome, Italy

Two female patients with recent diagnosis of systemic lupus erythematosus (SLE) are reported. Pulmonary arterial hypertension was diagnosed by Doppler echocardiography. Immunosuppressive therapy was started at the time of diagnosis of SLE. After 2 months of therapy, Doppler echocardiography was repeated and the estimated pulmonary artery systolic pressure was substantially decreased from 78 to 42 mmHg and from 67 to 42 mmHg, respectively, along with significant improvement of the clinical conditions.

Key Words: Systemic lupus erythematosus • Pulmonary arterial hypertension • Doppler echocardiography • Immunosuppressive therapy • Cyclosporin A.

Lupus, Vol. 2, No. 6, 367-369 (1993)
DOI: 10.1177/096120339300200606


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