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Lupus
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In Vitro Modulation of Anti-DNA Secreting Peripheral Blood Mononuclear Cells of Lupus Patients by Anti-Idiotypic Antibody of Pooled Human Intravenous Immune Globulin

Marilyn Evans

Immunology Research Laboratory, St. Luke's Hospital, Kansas City, MO 64111, USA

Nabih I. Abdou

Immunology Research Laboratory, St. Luke's Hospital, Kansas City, MO 64111, USA

Anti-idiotypic antibody and its F(ab')2 fragments prepared from pooled normal human IgG had a partial inhibitory effect on the spontaneous in vitro secretion of anti-DNA antibodies from blood mononuclear cells of lupus patients. The inhibitory effect was specific for anti-DNA secretion as the anti-idiotype failed to inhibit the spontaneous secretion of anti-tetanus toxoid in the same culture supernatants. Non-anti-DNA IgG or its F(ab')2 fragments from pooled normal human IgG had less inhibitory effect on anti-DNA secretion than the purifieed anti-Id. In vitro polyclonal IgG secretion by lupus blood mononuclear cells was equally inhibited by both the anti-idiotype and the non-anti-DNA IgG of pooled normal human IgG. There was no correlation between the in vitro suppression of anti-DNA and that of total IgG or of anti-tetanus toxoid antibody. Pooled normal human IgG could have a potential beneficial effect in the therapy of systemic lupus erythematosus by inhibiting anti-DNA production via an anti-idiotypic mechanism.

Key Words: Anti-DNA • Intravenous immune globulin • Lupus

Lupus, Vol. 2, No. 6, 371-375 (1993)
DOI: 10.1177/096120339300200607
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