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Lupus
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Antibodies Against Platelet-Activating Factor in Patients with Antiphospholipid Antibodies

Jordi Barquinero

Department of Internal Medicine, Hospital General Valle Hebrón, Barcelona, Spain

Josep Ordi-Ros

Department of Internal Medicine, Hospital General Valle Hebrón, Barcelona, Spain

Albert Selva

Department of Internal Medicine, Hospital General Valle Hebrón, Barcelona, Spain

Pilar Perez-Peman

Department of Internal Medicine, Hospital General Valle Hebrón, Barcelona, Spain

Miquel Vilardell

Department of Internal Medicine, Hospital General Valle Hebrón, Barcelona, Spain

Munther Khamashta

Lupus Arthritis Research Unit, St. Thomas' Hospital, London, UK

We have studied the specificity of antiphospholipid antibodies in 148 patients with autoimmune diseases, 120 patients with systemic lupus erythematosus and 28 with the primary antiphospholipid syndrome. In addition, 20 patients suffering from syphilis were studied. As a control group, 64 healthy volunteers were investigated. Patient and control serum samples were tested for binding to seven different phospholipid antigens by ELISA. Interestingly, 90% of the sera from syphilis patients and 6% of the autoimmune patients exhibited a significant binding to platelet-activating factor (PAF), a molecule similar to the structure of phosphatidylcholine. In addition, the IgG fraction from one of the lupus patients, which showed a high binding activity to PAF, was further affinity-purified using both liposomes and an affinity chromatography column. Preincubation of these antibodies with PAF inhibited subsequent binding to immobilized PAF. These observations might suggest a putative interaction of antiphospholipid autoantibodies with PAF 'in vivo', which may have, in some patients, important pathophysiological consequences.

Key Words: Thrombosis • Syphilis • Antiphospholipid • Platelet activating factor • SLE

Lupus, Vol. 3, No. 1, 55-58 (1994)
DOI: 10.1177/096120339400300111
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M. D. Lockshin
Antiphospholipid Antibody: Future Developments
Lupus, August 1, 1994; 3(4): 309 - 311.
[Abstract] [PDF]


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