SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Lupus
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Dov Golan, T.
Right arrow Articles by Sol, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dov Golan, T.
Right arrow Articles by Sol, K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Solar Ultraviolet Radiation Induces Enhanced Accumulation of Oxygen Radicals in Murine SLE-Derived Splenocytes in vitro

Theo Dov Golan

Department of Immunology, Bnai Zion Medical Center and Faculty of Medicine, Technion, PO Box 4940, Haifa 31048

Sigal Dan

Department of Immunology, Bnai Zion Medical Center and Faculty of Medicine, Technion, PO Box 4940, Haifa 31048

Hacham Haim

Department of Immunology, Bnai Zion Medical Center and Faculty of Medicine, Technion, PO Box 4940, Haifa 31048

Gottfried Varda

Department of Chemistry, Technion, Haifa, Israel

Kimel Sol

Department of Chemistry, Technion, Haifa, Israel

Although sunlight is known to induce generalized manifestation in systemic lupus erythematosus (SLE) patients, its underlying mechanism remains obscure. In the present study we have investigated whether UVA (320-400 nm), the most predominant UV component in solar radiation, induces enhanced accumulation of reactive oxygen species in murine SLE-derived cells (MRL/1) in comparison to normal cells (Balb/c), as measured by oxygen (O2) consumption, by means of a Clark-type electrode. Our data show enhanced O2 consumption by MRL/1 cells (which correlates with the formation of reactive oxygen species), accompanied by decreased viability, in comparison to irradiated normal cells. This finding suggests that increased accumulation of reactive oxygen species contributes to the enhanced photosensitivity observed in SLE patients.

Key Words: UVA radiation • reactive oxygen species • systemic lupus erythematosus

Lupus, Vol. 3, No. 2, 103-106 (1994)
DOI: 10.1177/096120339400300208
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement