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Lupus
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Review: Anti-Endothelial Cell Antibodies: a Need for Standardization

Yehuda Adler

Laboratory of Immunology, Medical School, Brest, France, Research Unit of Autoimmune Diseases, Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel

Konstantin Salozhin

Laboratory of Immunology, Medical School, Brest, France, Moscow Medical Academy, Moscow, Russia

Michelle Le Tonqueze

Laboratory of Immunology, Medical School, Brest, France

Yehuda Shoenfeld

Research Unit of Autoimmune Diseases, Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel

Pierre Youinou

Laboratory of Immunology, Medical School, Brest, France

Twenty years have passed since the original description of the anti-endothelial cell antibodies (AECA). It is widely acknowledged that the presence of circulating autoantibodies against endothelial cells surface antigens, found in a number of patients with connective tissue disease and vasculitis, is one of the driving mechanisms for the observed vascular injury and might be an important factor in initiating the pathogenesis of vascular abnormalities. AECA data regarding the prevalence, technical problems, presence with other autoantibodies, antigen distribution and immune endothelial cell injury associated with these autoantibodies, requires standardization for determining the precise pathophysiologic and immunologic role of anti-endothelial cell antibodies.

Key Words: Anti-endothelial cell antibodies • Antigen • Vasculitis • Connective tissue disease • Standardization

Lupus, Vol. 3, No. 2, 77-84 (1994)
DOI: 10.1177/096120339400300204
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This article has been cited by other articles:


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Y. Renaudineau, R. Revelen, Y. Levy, K. Salojin, B. Gilburg, Y. Shoenfeld, and P. Youinou
Anti-Endothelial Cell Antibodies in Systemic Sclerosis
Clin. Vaccine Immunol., March 1, 1999; 6(2): 156 - 160.
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