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Seronegative Antiphospholipid Syndrome Associated with Plasminogen Activator Inhibitor

Section of Rheumatology, Department of Medicine, LSU Medical Center, New Orleans, LA 70112, USA

Eve Scopelitis

Section of Rheumatology, Department of Medicine, LSU Medical Center, New Orleans, LA 70112, USA

Antiphospholipid syndrome is characterized by thrombosis, recurrent fetal loss, thrombocytopenia and is associated with the presence of antiphospholipid antibodies, especially anticardiolipin antibodies. We present a patient with the clinical features of antiphospholipid syndrome, namely recurrent venous and arterial thrombosis, recurrent abortions, thrombocytopenia and livido reticularis but with persistently negative serology for any type of antiphospholipid antibody. The possible existence of 'seronegative' antiphospholipid syndrome is proposed. Of additional interest in this patient is the presence of significantly elevated levels of plasminogen activator inhibitor. The role of this inhibitor, if any, in the antiphospholipid syndrome and/or seronegative antiphospholipid syndrome is not known and merits further study.

Key Words: Thrombosis • Anticardiolipin antibody • Plasminogen activator inhibitor • Vasculopathy

Lupus, Vol. 3, No. 3, 201-203 (1994)
DOI: 10.1177/096120339400300312


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