SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Lupus
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Harris, E.N.
Right arrow Articles by Pierangeli, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harris, E.N.
Right arrow Articles by Pierangeli, S.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Anticardiolipm Antibodies: Specificity and Function

E.N. Harris

Department of Medicine, Division or Rheumatology, Ambulatory Care Building, University of Louisville, Louisville, KY 40292, USA

Silvia Pierangeli

Department of Medicine, Division or Rheumatology, Ambulatory Care Building, University of Louisville, Louisville, KY 40292, USA

Antibodies detected by solid phase anticardiolipin immunoassays are heterogeneous but understanding the nature of this heterogeneity has proven difficult. Differences in any of the following features may account for differences in anticardiolipin antibodies: avidity for cardiolipin, phospholipid cross-reactivity, specificity for ß2 glycoprotein I (ß2GPI)-cardiolipin complexes, functional activity (as defined by the ability to inhibit phospholipid dependent coagulation reactions) and specificities for different conformations of phospholipids. Understanding these differences may be important in explaining the variations in clinical presentation of patients with these antibodies. This review attempts to define and discuss anticardiolipin heterogeneity.

Key Words: Anticardiolipin antibodies • Function • Specificity

Lupus, Vol. 3, No. 4, 217-222 (1994)
DOI: 10.1177/096120339400300403
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
L. Gu, A. Weinreb, X.-P. Wang, D. J. Zack, J.-H. Qiao, R. Weisbart, and A. J. Lusis
Genetic Determinants of Autoimmune Disease and Coronary Vasculitis in the MRL-lpr/lpr Mouse Model of Systemic Lupus Erythematosus
J. Immunol., December 15, 1998; 161(12): 6999 - 7006.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
P. Robbins, M. Forrest, and D. Royston
Hypercoagulable States
Seminars in Cardiothoracic and Vascular Anesthesia, November 1, 1997; 1(4): 295 - 318.
[Abstract] [PDF]


Advertisement