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Lupus
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Deforming Arthropathy of the Hands in Systemic Lupus Erythematosus is Associated with Antibodies to SSA/Ro and to SSB/La

Franco Franceschini

Clinical Immunology Unit, Spedali Civili; University of Brescia, 25100 Brescia, Italy

Lucia Cretti

Clinical Immunology Unit, Spedali Civili; University of Brescia, 25100 Brescia, Italy

Marzia Quinzanini

Clinical Immunology Unit, Spedali Civili; University of Brescia, 25100 Brescia, Italy

Fabio Lodi Rizzini

Clinical Immunology Unit, Spedali Civili; University of Brescia, 25100 Brescia, Italy

Roberto Cattaneo

Clinical Immunology Chair, University of Brescia, 25100 Brescia, Italy

Thirteen patients with systemic lupus erythematosus and deforming arthropathy (DA) of the hands were compared with 111 patients with SLE without deforming arthropathy. Clinical features were comparable in the two groups. Patients fulfilling criteria for mixed connective tissue disease (MCTD) were not included in the present study. A higher prevalence of antibodies to SSA/Ro (P < 0.0125) and SSB/La (P < 0.004) were found in the SLE-DA group. The detection of antibodies to SSA/Ro and SSB/La was even more strictly associated with DA in SLE antibodies to SSA/Ro alone (P < 0.002). Regarding the fine specificity of anti-SSA/Ro, a prevalent response to the 52 kD protein of the Ro antigen was found. We conclude that patients with SLE developing deformities of the hands belong to a subset of patients with circulating antibodies to SSA/Ro, particularly to the 52 kD component, and to SSB/La.

Key Words: SLE • Deforming arthropathy • Anti-SSA/Ro • Anti-SSB/La antibody

Lupus, Vol. 3, No. 5, 419-422 (1994)
DOI: 10.1177/096120339400300510
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This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
R M van Vugt, R H W M Derksen, L Kater, and J W J Bijlsma
Deforming arthropathy or lupus and rhupus hands in systemic lupus erythematosus
Ann Rheum Dis, September 1, 1998; 57(9): 540 - 544.
[Abstract] [Full Text]


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