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Role of Genetic Factors in Drug-Related Autoimmunity

Division of Immunology, Department of Medicine, University of Cincinnati Medical Center, M.L. 563, Cincinnati. Ohio 45267-0563, USA, Histocompatibility Laboratory, Hoxworth Blood Center, University of Cincinnati Medical Center, M.L. 563, Cincinnati, Ohio 45267-0563, USA

Anne-Barbara Mongey

Division of Immunology, Department of Medicine, University of Cincinnati Medical Center, M.L. 563, Cincinnati. Ohio 45267-0563, USA

Although there is evidence to suggest that genetic factors play a major role in the pathogenesis of many of the rheumatic diseases, far less is known of their role in the induction and expression of human autoimmunity resulting from long-term exposure to drugs, chemicals and environmental agents.

Pharmacogenetic factors represent an important source of interindividual variation in response to drugs; most research to date has focused on genetic polymorphism of drug metabolism via N-acetylation, S-methylation or cytochrome P-450-catalyzed oxidation.

In drug-related autoimmunity, there is limited evidence that the host's genetic background plays a major role beyond the expression of autoantibodies.

More recent prospective studies have concentrated on the association of MHC-genes in the expression of autoimmunity and the susceptibility of patients to develop drug-related clinical syndromes.

Key Words: Genetic factors • Drugs • Autoimmunity

Lupus, Vol. 3, No. 6, 443-447 (1994)
DOI: 10.1177/096120339400300603


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