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Hypergammaglobulinemic purpura of Waldenstrom associated with systemic lupus erythematosus: report of a case and review of the literature

Division of Rheumatology and Immunology, University of Southern California, Department of Medicine, Los Angeles, USA

Mary M Stimmer

Division of Rheumatology and Immunology, University of Southern California, Department of Medicine, Los Angeles, USA

Francisco P Quismorio, JR

Division of Rheumatology and Immunology, University of Southern California, Department of Medicine, Los Angeles, USA

A patient with hyperglobulinemic purpura of Waldenstrom and systemic lupus erythematosus is reported. The coexistence of these two conditions which share a number of common clinical and laboratory features is rare. Treatment of the patient with prednisone, colchicine and hydroxy chloroquine led to the improvement of the cutaneous vasculitis and a drop in ESR, serum gamma globulins and IgM and IgG rheumatoid factors. The features of nine other cases and the immunopathogenesis of the disease are reviewed.

Key Words: Hypergammaglobulinemic purpura • Cutaneous vasculitis • Systemic lupus erythematosus • IgG rheumatoid factors

Lupus, Vol. 4, No. 1, 19-22 (1995)
DOI: 10.1177/096120339500400105


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