This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Samsonov, M. Y Articles by Fuchs, D. Search for Related Content PubMed Articles by Samsonov, M. Y Articles by Fuchs, D. Social Bookmarking                   What's this?

Serum soluble markers of immune activation and disease activity in systemic lupus erythematosus

Laboratory of Clinical Immunology, Cardiology Research Center, Moscow, Russia

Gernot P Tilz

Department of Internal Medicine, University of Graz, Graz, Austria

Olga Egorova

Institute of Rheumatology, Russian Medical Academia, Moscow, Russia

Gilbert Reibnegger

Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria

Rimma M Balabanova

Institute of Rheumatology, Russian Medical Academia, Moscow, Russia

Eugeney L Nassonov

Laboratory of Clinical Immunology, Cardiology Research Center, Moscow, Russia

Valentina A Nassonova

Institute of Rheumatology, Russian Medical Academia, Moscow, Russia

Helmut Wachter

Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria

Dietmar Fuchs

Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria

We investigated a possible association between markers of immune activation and disease activity in 52 patients with systemic lupus erythematosus (SLE). Serum concentrations of neopterin, beta- 2-microglobulin, 55 kD-type soluble tumor necrosis factor receptor, soluble interleukin-2 receptor and soluble CD8 were compared to the Index of European Consensus Lupus Activity Measurement (ECLAM). All markers of immune activation, except sCD8, significantly correlated with ECLAM. Stepwise multiple linear regression analysis revealed erythrocyte sedimentation rate and neopterin to correlate best with ECLAM (multiple correlation coefficient = 0.74, P < 0.001). The study shows that serum neopterin concentrations are a useful independent index for disease activity in SLE. The finding of enhanced concentrations of various parameters of immune activation in patients confirm a role of the T cell and macrophage activation in the pathogenesis of SLE.

Key Words: Systemic lupus erythematosus • Disease activity • Neopterin • Soluble tumor necrosis factor receptor • Soluble interleukin-2 receptor

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				H. Schennach, C. Murr, C. Larcher, W. Streif, E. Pastner, D. Zaknun, D. Schonitzer, and D. Fuchs Neopterin Concentrations in Cord Blood: A Single-Cohort Study of Paired Samples from 541 Pregnant Women and Their Newborns Clin. Chem., November 1, 2002; 48(11): 2059 - 2061. [Full Text] [PDF]

				H. Schennach, C. Murr, E. Gachter, P. Mayersbach, D. Schonitzer, and D. Fuchs Factors Influencing Serum Neopterin Concentrations in a Population of Blood Donors Clin. Chem., April 1, 2002; 48(4): 643 - 645. [Full Text] [PDF]

				C. Schubert, A. Lampe, G. Rumpold, D. Fuchs, P. Konig, E. Chamson, and G. Schussler Daily Psychosocial Stressors Interfere With the Dynamics of Urine Neopterin in a Patient With Systemic Lupus Erythematosus: An Integrative Single-Case Study Psychosom Med, November 1, 1999; 61(6): 876 - 882. [Abstract] [Full Text] [PDF]

				C. Murr, A. Bergant, M. Widschwendter, K. Heim, H. Schrocksnadel, and D. Fuchs Neopterin Is an Independent Prognostic Variable in Females with Breast Cancer Clin. Chem., November 1, 1999; 45(11): 1998 - 2004. [Abstract] [Full Text] [PDF]

				A. C M. Kobold, C. G M Kallenberg, and J. W. C. Tervaert Monocyte activation in patients with Wegener's granulomatosis Ann Rheum Dis, April 1, 1999; 58(4): 237 - 245. [Abstract] [Full Text]

				C. S. Mantzoros, S. Moschos, I. Avramopoulos, V. Kaklamani, A. Liolios, D. E. Doulgerakis, I. Griveas, N. Katsilambros, and J. S. Flier Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor-{alpha} System in Humans J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3408 - 3413. [Abstract] [Full Text] [PDF]