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Lack of relationship between human immunodeficiency virus infection and systemic lupus erythematosusSystemic Autoimmune Diseases Unit, Department of Internal Medicine
Department of Microbiology, Hospital Clinic, Barcelona, Catalonia, Spain
Systemic Autoimmune Diseases Unit, Department of Internal Medicine
Systemic Autoimmune Diseases Unit, Department of Internal Medicine
Systemic Autoimmune Diseases Unit, Department of Internal Medicine
Department of Microbiology, Hospital Clinic, Barcelona, Catalonia, Spain
Systemic Autoimmune Diseases Unit, Department of Internal Medicine The objective of this work was to determine whether HIV-1 and HIV-2 could be involved in the pathogenesis of systemic lupus erythematosus (SLE). Seventy-five consecutive Caucasian patients with SLE presenting at one institution over a 2-year period were studied. Serum samples were surveyed for anti-HIV-1 antibodies by a commercial ELISA coated with HIV-1-p24. For confirmation, conventional immunoblots were performed with the following antigens: HIV-1-gp41, p31, p24 and p17 (recombinant) and HIV-2-gp36 (synthetic peptide). Additionally, Western blots with HIV-1-gp160, gp120, gp41, p65, p51, p24 and p18 bands were applied. Seventeen (23%) patients exhibited reactivity with HIV-1-p24 in the ELISA, but in the immunoblots and Western blots these sera samples were negative. Patients with SLE may exhibit a reactivity with HIV-1-p24 in the ELISA for HIV infection screening but not in the confirmatory blots. This false-positive reactivity is probably due to molecular mimicry between autoantigens and retroviruses or a contaminant or artefacts in the antigen preparation procedure.
Key Words: Systemic lupus erythematosus • Human immunodeficiency virus • Immunoblot
Lupus, Vol. 4, No. 1,
47-49 (1995) This article has been cited by other articles:
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