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Association between HLA class II antigens and primary antiphospholipid syndrome from the South of Spain

Unidad de Enfermedades Autoimmunes Sistémicas, Servicio de Medicina Interna, Hospital Regional del Servicio Andaluz de S alud, Málaga

MJ Cuadrado

Sección de Reumatologia, Hospital Universitario 'Reina Sofia', Córdoba

P. Ocón

Secci6n de Immunologia, Hospital Regional del Servicio Andaluz de Salud

A. Alonso

Secci6n de Immunologia, Hospital Regional del Servicio Andaluz de Salud

A. Gutierrez

Seccion de Bioquimica, Servicio de Laboratorio, Hospital Regional del Servicio Andaluz de Salud, Málaga, Spain

M. Guil

Unidad de Enfermedades Autoimmunes Sistémicas, Servicio de Medicina Interna, Hospital Regional del Servicio Andaluz de S alud, Málaga

MI Grana

Unidad de Enfermedades Autoimmunes Sistémicas, Servicio de Medicina Interna, Hospital Regional del Servicio Andaluz de S alud, Málaga

E. de Ramón

Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed an association between PAPS and HLA-DQ7 (47% vs 25%1 P = 0.03), DR4 (32% vs 16%; P = 0.08) and DQ3 (63% vs 39%; P = 0.04). However, multivariant analysis confirmed the association with DQ7 (RR = 2.5; CI 80%:1.3-4.7) and DR4 (RR = 2.2; CI 80%:1.1-4.4) but not with DQ3. When we introduced DRw53 into this analysis, we noticed a DR4 confounding effect, with DQ7 (RR = 3.1; CI 80%: 1.7-5.8) and Drw53 (RR = 2.3; CI 80%: 1.2-4.4) remaining as the most important HLA antigens related to PAPS. In conclusion, in PAPS patients from the South of Spain, HLA-DQ7 antigen showed the highest relative risk for PAPS, followed by DRw53.

Key Words: HLA class II antigens • PAPS • S. Spain

Lupus, Vol. 4, No. 1, 51-55 (1995)
DOI: 10.1177/096120339500400111


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