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Lupus
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Development of anti-Sm and anti-DNA antibodies followed by clinical manifestation of systemic lupus erythematosus in an elderly woman with long-standing Sjögren's syndrome

Minoru Satoh

Department of Internal Medicine, National Murayama Hospital

Hajime Yamagata

Department of Internal Medicine, National Murayama Hospital

Fumie Watanabe

Department of Internal Medicine, National Murayama Hospital

Shoji Nakayama

Department of Internal Medicine, National Murayama Hospital

Takashi Ogasawara

Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

Takeshi Tojo

Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

Masashi Akizuki

Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

A 69-year-old Japanese women who had been followed up for 10 years as a primary Sjögren's syndrome, is reported. She suddenly developed serological and clinical characteristics of systemic lupus erythematosus (SLE): anti-Sm and anti-dsDNA antibodies followed by nephrotic syndrome and pancytopenia. This case suggests that the diagnosis of primary Sjögren's syndrome should be considered as tentative in certain cases and that the development of serological characteristics precede and are associated with the development of clinical symptoms of SLE.

Key Words: Systemic lupus erythematosus • Sjögren's syndrome • Anti-Sm antibodies • Antinuclear antibodies

Lupus, Vol. 4, No. 1, 63-65 (1995)
DOI: 10.1177/096120339500400113
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