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IgA antiphospholipid antibodies in HTLV-1-associated tropical spastic paraparesis

Louisiana State University Medical Center, New Orleans, Louisiana, USA

Owen St. C Morgan

University of The West Indies, Kingston, Jamaica, West Indies

EN Barton

University of The West Indies, Kingston, Jamaica, West Indies

M. Smikle

University of The West Indies, Kingston, Jamaica, West Indies

B. Hanchard

University of The West Indies, Kingston, Jamaica, West Indies

WA Blattner

National Institute of Health, Bethesda, Maryland, USA

Sarah Doggett

Louisiana State University Medical Center, New Orleans, Louisiana, USA

Azzudin E Gharavi

Louisiana State University Medical Center, New Orleans, Louisiana, USA

A retrovirus, human T cell lymphotropic virus type 1 (HTLV-1), is an essential but not a sufficient aetiologic factor for tropical spastic paraparesis (TSP). Because some TSP patients have biological false positive tests for treponemal infections (BFP-STS), we used ELISA to study BFP-STS and anticardiolipin antibodies in 42 Jamaican TSP patients. The data indicate that in TSP anticardiolipin antibodies occur in about 26% of patients, are associated with biological false positive treponemal serology, are relatively restricted to the IgA isotype and may be induced by HTLV-1 or other non- treponemal infections.

Key Words: phospholipid antibodies • tropical spastic paraparesis

Lupus, Vol. 4, No. 2, 138-141 (1995)
DOI: 10.1177/096120339500400210


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