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Lupus
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Role of ß2-glycoprotein I in the antiphospholipid antibody binding to endothelial cells

M. Le Tonquèze

Laboratory of Immunology. Brest University Medical School Hospital, BP 824, F29609 Brest cedex

K. Salozhin

Laboratory of Immunology. Brest University Medical School Hospital, BP 824, F29609 Brest cedex, Moscow Medical Academy, Moscow, Russia

M. Dueymes

Laboratory of Immunology. Brest University Medical School Hospital, BP 824, F29609 Brest cedex

J.-C. Piette

Department of Internal Medicine, La Pitié-Salpétrière Hospital, Paris France

V. Kovalev

Moscow Medical Academy, Moscow, Russia

Y. Shoenfeld

Department of Medicine B, Chaim Sheba Medical Centre, Tel-Hashomer, Israel

E. Nassonov

Moscow Medical Academy, Moscow, Russia

P. Youinou

Laboratory of Immunology. Brest University Medical School Hospital, BP 824, F29609 Brest cedex

A group of anticardiolipin antibodies (aCL) require ß2-glycoprotein I (ß2GPI) to recognize their target, which might be located on endothelial cells (EC) and/or platelets. Following incubation with epithelial cells, 13 of 30 lupus sera retained EC-reactive antibodies of the IgG, IgA and IgM isotypes. Associated aCL and anti-phosphatidylethanolamine antibodies were partly absorbed on eC as well as EC. The former antibodies were more efficiently removed in the presence than in the absence of the latter. The presence of ß2GPI in the affinity-purified aCL preparations may explain their binding to EC, as this cross-reaction was abrogated by the removal of the cofactor and restored by its re-introduction. Seventy four per cent of EC were faintly stained with polyclonal or monoclonal antibody directed to the cofactor. The ß 2GPI mediated aCL binding to EC membranes could thus be influential in the development of thrombosis and/or thrombocytopenia in aCL-positive patients.

Key Words: anti-endothelial cell antibody • anticardiolipin antibody • antiphosphatidylethanolamine antibody • ß2-glycoprotein I

Lupus, Vol. 4, No. 3, 179-186 (1995)
DOI: 10.1177/096120339500400304
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This article has been cited by other articles:


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P. Meroni, N. Del Papa, E. Raschi, P. Panzeri, M. Borghi, A. Tincani, G. Balestrieri, M. Khamashta, G. Hughes, T. Koike, et al.
Review : {beta}2-Glycoprotein I as a 'Cofactor' for anti-phospholipid reactivity with endothelial cells
Lupus, January 1, 1998; 7(2_suppl): S44 - S47.
[Abstract] [PDF]


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