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Lupus, Vol. 4, No. 3, 229-231 (1995)
DOI: 10.1177/096120339500400313

Penicillium marneffei infection in a patient with SLE

C.-Y. Lo

Department of Medicine, University of Hong Kong, Queen Mary Hosputal, Pokfulam, Hong Kong

D.T.M. Chan

Department of Medicine, University of Hong Kong, Queen Mary Hosputal, Pokfulam, Hong Kong

K.-Y. Yuen

Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong

F.-K. Li

Department of Medicine, University of Hong Kong, Queen Mary Hosputal, Pokfulam, Hong Kong

K.P. Cheng

Department of Medicine, University of Hong Kong, Queen Mary Hosputal, Pokfulam, Hong Kong

We describe a patient with SLE who was infected by the fungus Penicillium marneffei. She was initially misdiagnosed as having disseminated tuberculosis. The correct diagnosis was finally made by bone marrow culture and she responded to a prolonged course of amphotericin B, flucytosine and itraconazole. The clinical presentation and histology of penicilliosis are very similar to those of Mycobacterium tuberculosis. In Southeast Asia, penicilliosis should be considered as a differential diagnosis in patients with SLE who present with fever and lymphadenopathy.

Key Words: Penicillium marneffei • itraconazole


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