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Lupus
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Portal hypertension associated with anticardiolipin antibodies in a case of systemic lupus erythematosus

C. Takahaski

Second Department of Internal Medicine, School of Medicine

S. Kumagai

Second Department of Internal Medicine, School of Medicine, College of Medical Technology, Kyoto University, Kyoto 606, Japan

R. Tsubata

Second Department of Internal Medicine, School of Medicine

K.-I. Sorachi

Second Department of Internal Medicine, School of Medicine

S.-I. Ozaki

Second Department of Internal Medicine, School of Medicine

H. Imura

Second Department of Internal Medicine, School of Medicine

K. Nakao

Second Department of Internal Medicine, School of Medicine

A 26-year-old man with systemic lupus erythematosus (SLE) and a history of acute myocardial infarction developed portal hypertension accompanied by abnormal liver function and esophageal varices. As his clinical course suggested the possibility of antiphospholipid syndrome, a titer of anticardiolipin antibody (aCL) was serially measured using an enzyme immunoassay with ß2-glycoprotein I as a cofactor. The titer of aCL increased with the development of portal hypertension, and promptly decreased with the improvement of liver function just after corticosteroid therapy. The long-term course in this case suggests that aCL may cause portal hypertension associated with SLE.

Key Words: antiphospholipid syndrome (APS) • anticardiolipin antibody • portal hypertension

Lupus, Vol. 4, No. 3, 232-235 (1995)
DOI: 10.1177/096120339500400314
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