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Lupus
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Research methods for investigating causal relations between SLE disease variables and psychiatric symptomatology

G.L. Iverson

Department of Psychiatry and Behavioral Sciences, PO Box 26901, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190

K.W. Anderson

Department of Psychiatry and Behavioral Sciences, PO Box 26901, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190

L.M. McCracken

Department of Psychiatry, University of Chicago, USA

People with systemic lupus erythematosus (SLE) frequently experience psychiatric problems. Some researchers and clinicians presume that these psychiatric problems are a direct manifestation of the disease, while others suggest that psychosocial and environmental factors have greater etiological significance. The majority of the studies addressing these issues in patients with SLE are too methodologically limited to make confident conclusions regarding etiology. More methodologically sound research in this area is needed. This article describes some of the limitations in past research in the areas of sampling, measurement, research design, data analyses and data presentation. Suggestions for improved methodology in future research are offered.

Key Words: methodology • psychiatric problems

Lupus, Vol. 4, No. 4, 249-254 (1995)
DOI: 10.1177/096120339500400402


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