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Lupus, Vol. 4, No. 4, 324-326 (1995)
DOI: 10.1177/096120339500400417

Benign intracranial hypertension: a non-thrombotic complication of the primary antiphospholipid syndrome?

Giuseppe Orefice

Second Department of Neurology, Federico University

Gabriella De Joanna

Second Department of Neurology, Federico University

Maria Coppola

Second Department of Neurology, Federico University

Vincenzo Brancaccio

Coagulation Unit, Cardarelli Hospital, Naples, Italy

Paul R.J. Ames

Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK

Benign intracranial hypertension is a rare complication of systemic lupus erythematosus often attributed to cerebral sinus thrombosis which impairs venous drainage and cerebrospinal fluid outflow. We report the case of a woman with a primary antiphospholipid syndrome who developed benign intracranial hypertension with no actual evidence of venous cerebral thrombosis and with no other possible cause for this clinical manifestation than high titres of anticardiolipin antibodies and a lupus anticoagulant.

Key Words: antiphospholipid antibodies • benign intracranial hypertension


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