Lupus

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kiely, P.
Right arrow Articles by Marsh, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Kiely, P.
Right arrow Articles by Marsh, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Lupus, Vol. 4, No. 5, 407-411 (1995)
DOI: 10.1177/096120339500400512

Erythrocyte aplasia and systemic lupus erythematosus

Pdw Kiely

Department of Rheumatology, St. George's Hospital

CP McGuckin

Department of Haematology, St. George's Hospital, London SW17 OQT, UK

DA Collins

Department of Rheumatology, St. George's Hospital

DH Bevan

Department of Haematology, St. George's Hospital, London SW17 OQT, UK

Jcw Marsh

Department of Haematology, St. George's Hospital, London SW17 OQT, UK

Pure erythrocyte aplasia is a recognised feature of systemic lupus erythematosus (SLE); here we report two cases, one predating the onset of SLE, the other following a long period of disease quiescence. One case demonstrates the typical features of this disorder and was successfully treated with prednisolone. The second case is unusual in being resistant to immunosuppressive treatment. Bone marrow culture from the second patient revealed an inhibition of BFU-E colony formation in the presence of the patient's serum, indicating that a serum inhibitor of haemopoiesis was present. Furthermore, following T cell depletion of this patient's marrow, there was an increase in BFU-E, CFU-G and CFU-GM colony growth implicating, in addition, a possible T cell-mediated inhibition of marrow haemopoiesis. This is a novel observation and may explain the resistance shown by this patient to standard treatment.

Key Words: red cell aplasia-pure • haemopoiesis • cytokines


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
S Giannouli, M Voulgarelis, P D Ziakas, and A G Tzioufas
Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment
Ann Rheum Dis, February 1, 2006; 65(2): 144 - 148.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
T Walton, Y Karim, D Wright, M Khamashta, and G Hughes
The association of pure red cell aplasia with the antiphospholipid syndrome
Lupus, December 1, 2001; 10(12): 899 - 901.
[PDF]

Home page
 Rheumatology (Oxford)Home page
C. Duarte-Salazar, J. Cazarin-Barrientos, M. V. Goycochea-Robles, J. Collazo-Jaloma, and R. Burgos-Vargas
Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with cyclosporin A
Rheumatology, October 1, 2000; 39(10): 1155 - 1157.
[Full Text] [PDF]