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Prolactin levels and antinuclear antibody profiles in women tested for connective tissue disease

Department of Internal Medicine, University of Missouri and Harry S Truman Memorial Veterans' Hospital, Columbia, MO 65212

GC Sharp

Department of Internal Medicine and Chief, Division of Immunology and Rheumatology, University of Missouri, Columbia, MO 65212

G. Wang

Antinuclear Antibody Laboratory, University of Missouri, Columbia, MO 65212

C. Conley

Antinuclear Antibody Laboratory, University of Missouri, Columbia, MO 65212

Y. Takeda

Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912

SE Conroy

Department of Molecular Pathology, University College London Medical School, 46 Cleveland Street, London W1P 6DB, UK

SE Walker

Rheumatology Section, Harry S Truman Memorial Veterans' Hospital and Department of Internal Medicine, University of Missouri, Columbia, MO 65201

Hyperprolactinemia has been reported in some patients with active systemic lupus erythe matosus (SLE). To determine if there was an association between selected autoantibodies and hyperprolactinemia, we assayed prolactin concentrations in sera from women sub mitted to a reference antinuclear antibody laboratory. Autoantibody-positive samples were separated into groups that contained antibodies to double-stranded DNA (anti-DNA), anti bodies to SSA/Ro (anti-SSA/Ro), or antibodies to both SSA/Ro and SSB/La (anti-SSA/Ro- SSB/La). Results were compared with autoantibody-negative sera from age-matched women, submitted to the same laboratory. We also compared the study groups with a separate cohort of 84 healthy women who were not referred for autoantibody testing. Elevated prolactin levels were clustered in 20% of sera from anti-DNA-positive women 50 years of age. Twenty-one percent of anti-SSA/Ro-SSB/La-positive women < 50 years of age were hyperprolactinemic. Four of the 15 hyperprolactinemic women identified in this survey had no known cause of elevated prolactin. In the other 11 individuals, secondary causes such as hypothyroidism, pregnancy, chronic renal failure, and medications may have accounted for high serum prolactin values. We also examined sera by Western blot, to determine if immunoblot patterns were associated with elevated serum prolactin concentra tions. The hyperprolactinemic sera yielded novel bands migrating at 70 kd, 32 kd, and 16.5 kd.

This study confirmed the reported associations of hyperprolactinemia with SLE and Sjögren's syndrome. Multiple factors appeared to contribute to elevated serum prolactin levels in women with connective tissue diseases, and the presence of hyperprolactinemia was related to unique findings on immunoblot analysis.

Key Words: prolactin • systemic lupus erythematosus • autoantibodies

Lupus, Vol. 5, No. 1, 30-37 (1996)
DOI: 10.1177/096120339600500107


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