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Heart rate variability in patients with systemic lupus erythematosus

Albert Einstein College of Medicine, Bronx, New York, Divisions of Rheumatology and Cardiology, S.U.N.Y. Health Science Center at Brooklyn, NY, USA

IC McFarlane

Albert Einstein College of Medicine, Bronx, New York, Divisions of Rheumatology and Cardiology, S.U.N.Y. Health Science Center at Brooklyn, NY, USA

N. Goldberg

Albert Einstein College of Medicine, Bronx, New York, Divisions of Rheumatology and Cardiology, S.U.N.Y. Health Science Center at Brooklyn, NY, USA

EM Ginzler

Albert Einstein College of Medicine, Bronx, New York, Divisions of Rheumatology and Cardiology, S.U.N.Y. Health Science Center at Brooklyn, NY, USA

As patients with systemic lupus erythematosus (SLE) survive their episodes of disease activ ity, increasing morbidity is shown to be related to chronic cardiovascular complications. The objective of this study was to assess the cardiac parasympathetic autonomic functional status, as reflected by heart rate variability, in SLE patients with and without corticosteroid treatment. A cross-sectional study of SLE patients attending the Arthritis Clinic was done, using age and gender-matched controls. Thirty-four female patients, age 39 ± 11, were entered, 20 of whom were receiving steroids at the time of study. Time and frequency domain heart rate variability indices were significantly reduced in the SLE groups with and without corticosteroid therapy, as compared to controls. The indices were not, however, significantly different in the two SLE groups.

Key Words: systemic lupus erythematosus • heart rate variability • autonomic function • corticosteroids

Lupus, Vol. 5, No. 1, 44-48 (1996)
DOI: 10.1177/096120339600500109


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