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Lupus
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Mononeuritis multiplex in systemic lupus erythematosus: response to pulse intravenous cyclophosphamide

VM Martinez-Taboada

Rheumatology Division, Hospital Universitario 'M. Valdecilla', Facultad de Medicina, Universidad de Cantabria, Av. Valdecilla s/n, 39008 Santander, Spain

R. Blanco Alonso

Rheumatology Division, Hospital Universitario 'M. Valdecilla', Facultad de Medicina, Universidad de Cantabria, Av. Valdecilla s/n, 39008 Santander, Spain

J. Armona

Rheumatology Division, Hospital Universitario 'M. Valdecilla', Facultad de Medicina, Universidad de Cantabria, Av. Valdecilla s/n, 39008 Santander, Spain

JL Femandez-Sueiro

Rheumatology Division, Hospital Universitario 'M. Valdecilla', Facultad de Medicina, Universidad de Cantabria, Av. Valdecilla s/n, 39008 Santander, Spain

C. Gonzalez Vela

Rheumatology Division, Hospital Universitario 'M. Valdecilla', Facultad de Medicina, Universidad de Cantabria, Av. Valdecilla s/n, 39008 Santander, Spain

V. Rodriguez-Valverde

Rheumatology Division, Hospital Universitario 'M. Valdecilla', Facultad de Medicina, Universidad de Cantabria, Av. Valdecilla s/n, 39008 Santander, Spain

Severe mononeuritis multiplex in systemic lupus erythematosus (SLE) is quite rare and almost always accompanied by evidence of active disease in other organs, although occasionally it may be the presenting feature of the disease. We describe here two patients with SLE who presented a severe mononeuritis multiplex secondary to a necrotizing vasculitis which responded successfully to therapy with intravenous cyclophosphamide, and review the literature of similar cases.

Key Words: mononeuritis multiplex • necrotizing vasculitis • cyclophosphamide

Lupus, Vol. 5, No. 1, 74-76 (1996)
DOI: 10.1177/096120339600500114
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