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Lupus
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The role of ß2-glycoprotein I in the antiphospholipid syndrome

SA Krilis

Department of Immunology, Allergy and Infectious Disease and Department of Medicine, St George Hospital University of NSW

YH Sheng

Department of Immunology, Allergy and Infectious Disease and Department of Medicine, St George Hospital University of NSW

DA Kandiah

Department of Immunology, Allergy and Infectious Disease and Department of Medicine, St George Hospital University of NSW

Antiphospholipid antibodies were originally thought to bind negatively-charged (aniomic) phospholipids. Current evidence suggests that the target antigen is considerably more complex and includes ß2-glycoprotein I, a phospholipid-binding plasma protein. Our under standing of the pathophysiology of the antiphospholipid syndrome has increased exponen tially with a number of studies into the interactions of antiphospholipid antibodies and ß2-glycoprotein I.

Key Words: antiphospholipid syndrome • antiphospholipid antibodies • ß2-glycoprotein I

Lupus, Vol. 5, No. 2, 150-152 (1996)
DOI: 10.1177/096120339600500211
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