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Lupus
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Immunology of antiphospholipid antibodies and their interaction with plasma proteins

DA Kandiah

Department of Immunology, Allergy and Infectious Disease and Department of Medicine, University of New South Wales

SA Krilis

Department of Immunology, Allergy and Infectious Disease and Department of Medicine, University of New South Wales

'Antiphospholipid' (aPL) antibodies are of clinical importance because of their strong association with vascular thrombosis, recurrent pregnancy loss, thrombocytopenia and other clinical manifestations like livedo reticularis, chorea and cardiac valvular disease1. While aPL antibodies have traditionally been thought to be directed against negatively- charged (anionic) phospholipids, current evidence suggests that these autoantibodies recog nise protein-phospholipid complexes or the proteins themselves2-4. A number of candidate proteins have been investigated with the two most extensively researched being ß2 glycoprotein I and prothrombin.

Key Words: antiphospholipid antibodies • lupus anticoagulants • ß2-glycoprotein I • prothrom bin

Lupus, Vol. 5, No. 2, 153-155 (1996)
DOI: 10.1177/096120339600500212
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D A Kandiah and S A Krilis
Anti-{beta}2-glycoprotein I and anti-prothrombin antibodies in patients with the 'antiphospholipid' syndrome: Immunological specificity and clotting profiles
Lupus, June 1, 1998; 7(5): 323 - 332.
[Abstract] [PDF]


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