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Libman-Sacks endocarditis in the antiphospholipid syndrome: immunopathologic findings in deformed heart valves

Research Unit of Autoimmune Diseases and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel

I. Goldberg

Department of Pathology, Sheba Medical Center, Tel-Hashomer, Israel

M. Arad

Departments of Internal Medicine and Pathology, Beilinson Hospital, Petach Tikva

M. Hojnik

Research Unit of Autoimmune Diseases and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel

J. Ordi-Ros

internal Medicine 3° Planta, Vall D'Hebron, Barcelona, Spain

A. Afek

Department of Pathology, Sheba Medical Center, Tel-Hashomer, Israel

M. Blank

Research Unit of Autoimmune Diseases and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel

Y. Sandbank

Departments of Internal Medicine and Pathology, Beilinson Hospital, Petach Tikva

M. Vilardell-Tarres

internal Medicine 3° Planta, Vall D'Hebron, Barcelona, Spain

I. de Torres

internal Medicine 3° Planta, Vall D'Hebron, Barcelona, Spain

A. Weinberger

Departments of Internal Medicine and Pathology, Beilinson Hospital, Petach Tikva

RA Asherson

Rheumatic Diseases Unit, Department of Medicine, University of Capetown, School of Medicine, Capetown, South Africa

Y. Kopolovic

Department of Pathology, Sheba Medical Center, Tel-Hashomer, Israel

Y. Shoenfeld

Research Unit of Autoimmune Diseases and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel

Objective. To examine the potential immunologic mechanism and involvement of antiphos pholipid antibodies in the pathogenesis of heart valve lesions in patients with the antiphos pholipid syndrome (APS).

Methods. Immunoperoxidase and immunofluorescence staining methods were used to evaluate 13 heart valve specimens derived from eight patients with the APS, either primary or secondary to systemic lupus erythematosus. Primary antibodies to human immuno globulins, complement components, serum albumin and a monoclonal anti-idiotypic anti body to human anticardiolipin antibodies (aCL) were employed. Various tissue specimens from a patient with the APS as well as deformed and normal valves from subjects without the APS were used as controls.

Results. Linear subendothelial deposition consisting of immunoglobulins with complement components but not of a non-specific serum protein was found in deformed valves from patients with the APS. None of the control valves or tissues disclosed similar deposition. The same pattern and location of staining was obtained by the anti-idiotypic antibody to aCL. A significant amount of IgG immunoglobulins that bound to cardiolipin was eluted from a valve of a patient with secondary APS.

Conclusion. Deposits of immunoglobulins including aCL, and of complement components, are common in affected valves of patients with primary and secondary APS. Such deposits may be involved in the pathogenesis of valvular lesions.

Key Words: heart valves • Libman-Sacks endocarditis • antiphospholipid syndrome • anti cardiolipin antibodies • systemic lupus erythematosus

Lupus, Vol. 5, No. 3, 196-205 (1996)
DOI: 10.1177/096120339600500306


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