This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Tseng, C-E. Articles by Buyon, J. Search for Related Content PubMed PubMed Citation Articles by Tseng, C-E. Articles by Buyon, J. Pubmed/NCBI databases Medline Plus Health Information Lupus Social Bookmarking                         What's this?

Stability of immunoblot profile of anti-SSA/Ro-SSB/La antibodies over time in mothers whose children have neonatal lupus

Department of Medicine, Division of Rheumatology, New York University School of Medicine, Department of Rheumatic Diseases and Molecular Medicine, Hospital for Joint Diseases, New York, NY 10003, USA

F. Di Donato

Department of Medicine, Division of Rheumatology, New York University School of Medicine, Department of Rheumatic Diseases and Molecular Medicine, Hospital for Joint Diseases, New York, NY 10003, USA

JP Buyon

Department of Medicine, Division of Rheumatology, New York University School of Medicine, Department of Rheumatic Diseases and Molecular Medicine, Hospital for Joint Diseases, New York, NY 10003, USA

Neonatal lupus is strongly associated with antibodies reactive with SSA/Ro-SSB/La pro teins, independent of maternal disease activity or classification. We sought to determine whether the fine specificity of antibody profiles remains stable or evolves over time and whether these findings relate to clinical status. Sera from 23 mothers whose children had neonatal lupus (22 heart block, one skin) were evaluated by SDS-immunoblot. For each mother two samples were available at least 13 months apart; the mean duration of time between testing was 45 months ± 27 S.D. (range 13-108 months). Twenty-two of the 23 initial profiles were identical to the results obtained in a later sample. The health status of seven (30%) of 23 mothers changed after the birth of the affected infant but the immunoblot specificity of the antibodies remained unchanged. SLE was the initial and final diagnosis in the only mother whose profiles differed, with development of weak reactivity to 48 kD SSB/La in addition to the 52 kD SSA/Ro after 14 months. In conclusion, the fine specificity of anti-SSA/Ro-SSB/La antibodies as assessed by immunoblot is highly stable for years. Progression of clinical status was not associated with a concomitant change in antibody profile.

Key Words: systemic lupus erythematosus • SSA/Ro antibodies • SSB/La antibodies • neonatal lupus • autoantibody associated congenital heart block

Lupus, Vol. 5, No. 3, 212-215 (1996)
DOI: 10.1177/096120339600500308


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				T L Rivera, P M Izmirly, B K Birnbaum, P Byrne, J B Brauth, M Katholi, M Y Kim, J Fischer, R M Clancy, and J P Buyon Disease progression in mothers of children enrolled in the Research Registry for Neonatal Lupus Ann Rheum Dis, June 1, 2009; 68(6): 828 - 835. [Abstract] [Full Text] [PDF]

				E. Villain, N. Coastedoat-Chalumeau, E. Marijon, Y. Boudjemline, J.-C. Piette, and D. Bonnet Presentation and Prognosis of Complete Atrioventricular Block in Childhood, According to Maternal Antibody Status J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1682 - 1687. [Abstract] [Full Text] [PDF]

				A Brucato, A Jonzon, D Friedman, L D Allan, G Vignati, M Gasparini, J I Stein, S Montella, M Michaelsson, and J Buyon Proposal for a new definition of congenital complete atrioventricular block Lupus, June 1, 2003; 12(6): 427 - 435. [Abstract] [PDF]