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Lupus, Vol. 5, No. 3, 221-226 (1996)
DOI: 10.1177/096120339600500310

Long term follow-up of children with mixed connective tissue disease

R. Mier

Shriners Hospital, 1900 Richmond Road, Lexington, Kentucky, KY, USA

B. Ansell

Shriners Hospital, 1900 Richmond Road, Lexington, Kentucky, KY, USA

MA Hall

Shriners Hospital, 1900 Richmond Road, Lexington, Kentucky, KY, USA

N. Hasson

Shriners Hospital, 1900 Richmond Road, Lexington, Kentucky, KY, USA

J. Levinson

Shriners Hospital, 1900 Richmond Road, Lexington, Kentucky, KY, USA

D. Lovell

Shriners Hospital, 1900 Richmond Road, Lexington, Kentucky, KY, USA

M. Passo

Shriners Hospital, 1900 Richmond Road, Lexington, Kentucky, KY, USA

R. Rennebohm

Shriners Hospital, 1900 Richmond Road, Lexington, Kentucky, KY, USA

P. Woo

Shriners Hospital, 1900 Richmond Road, Lexington, Kentucky, KY, USA

Mixed connective tissue disease (MCTD) is characterized by features of more than one of the rheumatic disorders with antinuclear antibodies in a speckled pattern and with anti bodies to nuclear ribonucleoprotein (nRNP). MCTD is uncommon in children and long- term follow-up studies in children are infrequently reported. A retrospective review of clinical experience at five pediatric rheumatology centers provided 11 patients who met the following inclusion criteria:

(1) Kasukawa's criteria for MCTD1;

(2) presentation younger than 18th birthday;

(3) greater than five years of follow-up;

(4) completion of data collection form.

The widely varying outcomes of these 11 children with MCTD on long-term follow-up may lend doubt that this is a unique and distinctive rheumatologic disorder.

Key Words: mixed connective tissue disease • overlap syndrome • undifferentiated connective tissue disease • RNP antibodies


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