Lupus

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ben-Yehuda, A.
Right arrow Articles by Naparstek, Y.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Ben-Yehuda, A.
Right arrow Articles by Naparstek, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Lupus, Vol. 5, No. 3, 232-236 (1996)
DOI: 10.1177/096120339600500312

Lymph node cell vaccination against the lupus syndrome of MRL/lpr/lpr mice

A. Ben-Yehuda

Clinical Immunology and Allergy Unit, Department of Medicine

R. Bar-Tana

Clinical Immunology and Allergy Unit, Department of Medicine

A. Livoff

Department of Pathology, Hadassah University Hospital, Jerusalem

N. Ron

Department of Pathology, Hadassah University Hospital, Jerusalem

IR Cohen

Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel

Y. Naparstek

Clinical Immunology and Allergy Unit, Department of Medicine

Immunization with pathogenic lymphoid cells has been shown to induce resistance to disease in experimental animal models of cell mediated autoimmunity. In the present work we tested the effectiveness of this approach in a spontaneous murine autoimmune disease, the MRL/lpr/lpr (MRL/1) murine lupus model. We now report that the anti-DNA anti bodies and glomerulonephritis of MRL/1 mice could be prevented by the adoptive transfer of spleen cells from MRL/+ mice that had been vaccinated with MRL/1 lymph node T lymphocytes, but not by direct vaccination of MRL/1 mice with their cells. These results indicate that the lupus of MRL/1 mice is susceptible to regulation by adoptive vaccination and that these autoimmune mice lack the ability to raise a suppressive response against their own pathogenic cells.

Key Words: Lupus • MRL-lpr/lpr • Vaccination • T cells


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 LupusHome page
Z-G Li, R Mu, Z-P Dai, and X-M Gao
T cell vaccination in systemic lupus erythematosus with autologous activated T cells
Lupus, November 1, 2005; 14(11): 884 - 889.
[Abstract] [PDF]