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Lupus
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Common variable immunodeficiency in a patient with systemic lupus erythematosus

Ajg Swaak

Department of Rheumatology, Dr. Daniel den Hoed Clinic, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands

HG van den Brink

Department of Autoimmune Diseases, Central Laboratory Red Cross Blood Transfusion Service, Plesmanlaan 125, Amsterdam, The Netherlands

This report describes a young girl who developed systemic lupus erythematosus at the age of 11. In the years thereafter a conversion took place from hypergammaglobulinemia to hypogammaglobulinemia with the absence of circulating and bone marrow B-cells. Some aspects of the aetiopathogenesis of common variable immunodeficiency are discussed.

Key Words: systemic lupus erythematosus • common variable immunodeficiency • B cells

Lupus, Vol. 5, No. 3, 242-246 (1996)
DOI: 10.1177/096120339600500314
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