This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Satoh, M. Articles by Homma, M. Search for Related Content PubMed PubMed Citation Articles by Satoh, M. Articles by Homma, M. Pubmed/NCBI databases Medline Plus Health Information Autoimmune Diseases Joint Disorders Salivary Gland Disorders Sjogren's Syndrome Social Bookmarking                         What's this?

Late development of anti-La/SS-B antibodies in a patient with Sjogren's syndrome and high titer anti-Ro/SS-A antibodies

Division of Rheumatology and Immunology, Departments of Medicine, and Microbiology and Immunology, the Thurston Arthritis Research Center and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7280, USA

KJ Hamilton

Division of Rheumatology and Immunology, Departments of Medicine, and Microbiology and Immunology, the Thurston Arthritis Research Center and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7280, USA

JJ Langdon

Division of Rheumatology and Immunology, Departments of Medicine, and Microbiology and Immunology, the Thurston Arthritis Research Center and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7280, USA

M. Akizuki

Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160, Japan

H. Yamagata

Department of Internal Medicine, National Murayama Hospital, Tokyo, 208, Japan

S. Nakayama

Department of Internal Medicine, National Murayama Hospital, Tokyo, 208, Japan

WH Reeves

Division of Rheumatology and Immunology, Departments of Medicine, and Microbiology and Immunology, the Thurston Arthritis Research Center and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7280, USA

M. Homma

Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160, Japan

The frequent coexistence of anti-Ro and anti-La autoantibodies is well described, however, there is little evidence of sequential development of these two autoantibodies. We report a case of typical Sjogren's syndrome with high titer anti-Ro antibodies, who subsequently developed anti-La antibodies later in the course. This case suggests that the anti-La anti bodies may actually follow the anti-Ro antibodies in some cases as hypothesized in the concept of linked set of autoantibodies, analogous to development of anti-Sm in certain anti-nRNP antibody positive SLE patients and animal models.

Key Words: anti-La antibodies • anti-Ro antibodies • Sjogren's syndrome • antinuclear anti bodies

Lupus, Vol. 5, No. 4, 337-339 (1996)
DOI: 10.1177/096120339600500417


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?