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SLE mortality in an oriental population

Department of Rheumatology & Immunology, Tan Tock Seng Hospital

A. Seow

Department of Community, Occupational and Family Medicine, National University of Singapore

KH Leong

Department of Rheumatology & Immunology, Tan Tock Seng Hospital

HH Chng

Department of Rheumatology & Immunology, Tan Tock Seng Hospital

We analysed the causes of 67 deaths, over a 4 y period, in our oriental population with systemic lupus erythematosus (SLE). The median disease duration was 48±60.5 months (range 1—250 months). The mean age at diagnosis and death were 30 and 35.1 y respectively. SLE alone accounted for death in 30 patients (44.8%), infection in 27 (40.3%), pulmonary embolism in 5 (7.5%), malignancy in 4 (5.9%) and rheumatic heart disease in 1 (1.5%). The major organ involvement in those with active disease at death were SLE related thrombocytopenia (n = 23/44, 52.3%), nephritis (n=21/44), 47.7%), cerebral lupus ( n=16/44, 36.4%), and pulmonary haemorrhage (n=12/44, 27.3%). As in other series, SLE and infection were the principal causes of death in our population. During this 4 y period, there was no late death due to atherosclerosis.

Key Words: systemic lupus erythematosus • mortality • oriental • thrombocytopenia • pulmonary haemorrhage

Lupus, Vol. 6, No. 1, 27-31 (1997)
DOI: 10.1177/096120339700600104


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