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Lupus
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Systemic lupus erythematosus with acanthosis nigricans, hyperpigmentation, and insulin receptor antibody

J.S. Baird

Fellow in Pediatric Critical Care at New York Hospital/Cornell Medical Center, New York

J.L. Johnson

Clinical Pediatrics at University of Southern California School of Medicine

D. Elliott-Mills

Clinical Pediatrics at University of Southern California School of Medicine

L.M. Opas

University of Southern California School of Medicine

Acanthosis nigricans, insulin receptor antibody, and systemic lupus erythematosus are associated in the potentially lethal syndrome of type B insulin resistance. Hyperpigmentation has been reported rarely, while glucose intolerance is common in these patients. We report an adolescent girl with acanthosis nigricans, hyperpigmentation, insulin receptor antibody, and systemic lupus erythematosus without glucose intolerance. Insulin resistance may be mild or transient in some patients with type B insulin resistance. Resolution of skin lesions was noted during therapy of SLE, and was associated with disappearance of insulin receptor antibody.

Key Words: acanthosis nigricans • hyperpigmentation • lupus erythematosus • systemic • insulin resistance

Lupus, Vol. 6, No. 3, 275-278 (1997)
DOI: 10.1177/096120339700600311
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This article has been cited by other articles:


Home page
 LupusHome page
Y Qing, J-G Zhou, and G Yuan
Systemic lupus erythematosus presenting as hypoglycaemia with insulin receptor antibodies and insulin autoantibodies
Lupus, April 1, 2009; 18(5): 457 - 459.
[Abstract] [PDF]


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