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Congenital heart block and subsequent connective tissue disorder in adolescence

Rheumatology Unit, Department of Internal Medicine, Centro de Educación Médica e Investigaciones Clinicas (CEMIC), Buenos Aires, Argentina

D. Carrillo

Rheumatology Service, Department of Internal Medicine, Hospital Pablo Soria, Jujuy, Jujuy, Argentina

M. Reichlin

Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA

A young girl born to a mother with systemic lupus erythematosus (SLE) had congenital heart block and developed symptoms of a connective tissue disorder at the age of 13 y. When first seen at the age of 15 y she was found to have an unclassified connective tissue disorder and to be seropositive for anti Ro/SSA and U1 RNP. This constellation of clinical/serological features has not been described among the reported handful of patients with congenital heart block and subsequent development of a connective tissue disorder.

Key Words: congenital heart block • neonatal lupus • anti Ro/SSA antibodies • familial connective tissue disease

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