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IgA deficiency and SLE: prevalence in a clinic population and a review of the literature

Centre for RheumatologyBloomsbury Rheumatology Unit, Department of Medicine, University College London, c.o. Arthur Stanley House, 40-50 Tottenham Street, London W1P 9PG

DA Isenberg

Centre for RheumatologyBloomsbury Rheumatology Unit, Department of Medicine, University College London, c.o. Arthur Stanley House, 40-50 Tottenham Street, London W1P 9PG

An association between systemic lupus erythematosus (SLE) and immunoglobulin A (IgA) deficiency has been reported previously and may have therapeutic consequences for patients who require treatment with intravenous immunoglobulin. We report the prevalence of IgA deficiency in a clinic population of 96 patients with SLE. Five patients were found to be consistently IgA deficient. These patients were more likely to be West Indian, to have anti-Sm and anti-La antibodies and to have a speckled pattern of antinuclear antibody. There were no significant differences in clinical features between IgA deficient and other SLE patients, nor in SLE-related HLA alleles. We thus confirm the increased prevalence of IgA deficiency in patients with SLE. A review of the literature is presented and we speculate on the nature of the link between IgA deficiency and SLE.

Key Words: IgA deficiency • lupus erythematosus • systemic

Lupus, Vol. 6, No. 4, 390-394 (1997)
DOI: 10.1177/096120339700600408


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