This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Scofield, R. Articles by Reichlin, M. Search for Related Content PubMed PubMed Citation Articles by Scofield, R. Articles by Reichlin, M. Pubmed/NCBI databases Medline Plus Health Information Joint Disorders Salivary Gland Disorders Sjogren's Syndrome Social Bookmarking                         What's this?

Immunologically restricted and inhibitory anti-Ro/SSA in monozygotic twins

Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center, Department of Veterans Affairs Medical Center, Oklahoma City, OK

BT Kurien

Arthritis and Immunology Program, Oklahoma Medical Research Foundation

M. Reichlin

Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, University of Oklahoma Health Sciences Center

A pair of monozygotic twins with Sjögren's syndrome are described who both have large amounts of anti-Ro/SSA in their sera by ELISA, but no precipitin in double immunodiffusion. Unique among previously encountered specimens, sera from the twins inhibit the formation of Ro/SSA precipitins in double immunodiffusion by known anti-Ro/SSA positive SLE patients. The twins have near identical, clonally restricted anti-Ro/SSA autoantibodies as evaluated by isoelectric focusing and bind the same 60 kD Ro/SSA peptides. Thus, this pair of monozygotic twins has an identical fine specificity in their immune response to 60 kD Ro/SSA, despite potential differences in their immune response generated by random processes in the formation of immunoglobulin molecules and T cell receptors. These data imply that the anti-Ro/SSA found in these sera binds less than three epitopes such that soluble antigen/antibody complexes are formed instead of an insoluble complex that precipitates.

Key Words: Sjögren's syndrome • anti-Ro/SSa • twins • autoantibodies

Lupus, Vol. 6, No. 4, 395-398 (1997)
DOI: 10.1177/096120339700600409


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S.A. Mathews, B.T. Kurien, and R.H. Scofield Oral Manifestations of Sjogren's Syndrome Journal of Dental Research, April 1, 2008; 87(4): 308 - 318. [Abstract] [Full Text] [PDF]

				J. Lee, P. Merry, R. Ball, and K. Gaffney Like father, like son Ann Rheum Dis, December 1, 2007; 66(12): 1686 - 1687. [Full Text] [PDF]

				R. H. Scofield, S. Asfa, D. Obeso, R. Jonsson, and B. T. Kurien Immunization with Short Peptides from the 60-kDa Ro Antigen Recapitulates the Serological and Pathological Findings as well as the Salivary Gland Dysfunction of Sjogren's Syndrome J. Immunol., December 15, 2005; 175(12): 8409 - 8414. [Abstract] [Full Text] [PDF]