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Review : Lack of linkage between anti-nuclear antibody or clinical features of systemic lupus erythematosus (SLE) and TCR-A/Vß loci in families of subjects with SLE

Department of Rheumatology, Royal North Shore Hospital, St. Leonards, Sydney, NSW 2065, Australia

D. Morris

Department of Rheumatology, Royal North Shore Hospital, St. Leonards, Sydney, NSW 2065, Australia

H. Dunckley

Red Cross Blood Transfusion Service, Sydney, Australia, 2001

D. Grennan

Department of Rheumatology, Wrightington Hospital for Joint Disease, Nr. Wigan, Lancs, UK

N. Manolios

Department of Rheumatology, Royal North Shore Hospital, St. Leonards, Sydney, NSW 2065, Australia

The role of the TCR-A and TCR-Vß genes in the genetic predisposition to SLE expression and anti nuclear antibody (ANA) production were examined by linkage analysis in eighteen multiplex and forty-three simplex SLE families. All subjects were Caucasian. A significantly increased prevalence of positive ANAs in first-degree relatives of SLE patients from multiplex families was noticed compared to that of simplex families. Linkage between TCR-A/Vß genes and SLE expression and ANA production were analysed by affected sib-pair method. Results showed that the haplotypes identical by descent sharing TCR-A and TCR-Vß genes in the affected sib-pairs was not different from that expected (P = 0.93 and P = 0.74, respectively). There was no linkage between ANA positivity and TCR-A and TCR-Vß genes in ANA positive sib-pairs from both multiplex and simplex families. This study suggests that germline TCR-A and TCR-Vß gene loci confer no susceptibility to ANA and SLE expression.

Key Words: systemic lupus erythematosus • genetic susceptibility • T-cell antigen receptor genes • linkage analysis • affects sib-pairs

Lupus, Vol. 6, No. 6, 527-532 (1997)
DOI: 10.1177/096120339700600609


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