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Lupus
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Review : Grand Rounds from International Lupus Centres Accelerated atherosclerosis and coronary disease in SLE

Y. Farhey

Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine; 231 Bethesda Avenue, Cincinnati, Ohio 45267-0563, USA

E.V. Hess

Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine; 231 Bethesda Avenue, Cincinnati, Ohio 45267-0563, USA

Atherosclerosis may represent a significant cause of death and morbidity in patients with systemic lupus erythematosus. Coronary involvement is more premature in lupus patients. We present the case of a young woman diagnosed with SLE at the age of 20 years who had a myocardial infarction at age 29 years. We review the mechanisms of atherosclerosis, the interrelations between atherosclerosis and autoimmunity, and between atherosclerosis and SLE. We also review the risk factors, influence of disease and treatment and the guidelines for management of accelerated atherosclerosis in lupus patients.

Key Words: accelerated atherosclerosis • coronary disease

Lupus, Vol. 6, No. 7, 572-577 (1997)
DOI: 10.1177/096120339700600704
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