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Review : Abnormalities in the protein C anticoagulant pathway detected by a novel assay using human thrombomodulin

Laboratory for Pharmacology, Institute for Life Science Research, Asahi Chemical Industry Co., Ltd, Oh-hito, Tagata, Shizuoka 410-23

M. Sata

Laboratory for Pharmacology, Institute for Life Science Research, Asahi Chemical Industry Co., Ltd, Oh-hito, Tagata, Shizuoka 410-23

K. Gomi

Laboratory for Pharmacology, Institute for Life Science Research, Asahi Chemical Industry Co., Ltd, Oh-hito, Tagata, Shizuoka 410-23

Y. Maruyama

Third Internal Medicine, Kagoshima University School of Medicine

M. Osame

Third Internal Medicine, Kagoshima University School of Medicine

I. Maruyama

Department of Clinical Laboratory Medicine, Kagoshima University School of Medicine, Kagoshima, Kagoshima 810, Japan

We developed a novel assay using human thrombomodulin (TM), which detected overall abnormalities in the protein C anticoagulant pathway (PC pathway). This assay indicates the degree of inhibition of prothrombinase by TM, which is represented as the percentage of prothrombinase inhibition by 25 ng/ml of TM, termed PIP ₂₅ (Prothrombinase Inhibition Percentage). We examined PIP₂₅ in plasma samples from patients with systemic lupus erythematosus (SLE) with or without lupus anticoagulant (LA), patients with Behret's disease (BD), and patients with miscellaneous thrombotic vasculitis and compared these with the PIP₂₅ of plasma samples from healthy volunteers in Japan. The PIP₂₅s were significantly lower in SLE alone (35.5 ± 12.8%, P = 0.036) and SLE with LA (33.0 ± 13.3%, P = 0.030) and BD (33.3 ± 13.4%, P = 0.010) than those in healthy volunteers (43.5 ± 10.7%). There was no significance between healthy PIP₂₅ and those with miscellaneous thrombotic vasculitis (44.2±8.4%, P = 0.823). These results suggest that the abnormalities of the protein C anticoagulant pathway were present in patients with SLE(LA) and BD.

Key Words: thrombomodulin • protein C • protein S • systemic lupus erythematosus • Behçet's disease

Lupus, Vol. 6, No. 7, 590-596 (1997)
DOI: 10.1177/096120339700600706


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