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Development of systemic lupus erythematosus in a rheumatoid arthritis patient with anti-ribosomal P protein antibody

The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo

T. Mimura

The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo

H. Kanda

The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo

N. Morino

The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo

Y. Yazaki

The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo

Y. Nojimal

Department of Clinical Immunology and AIDS Research Center, The Institute of Medical Science, University of Tokyo, Tokyo, Japan

We describe a patient with rheumatoid arthritis (RA) whose sera contained a high titre of an antibody targeting cytoplasmic ribosomal P proteins (anti-P). This association preceded by 6 years the development of serological and clinical manifestations of systemic lupus erythematosus (SLE). The clinical significance of anti-P for the diagnosis of SLE is discussed.

Key Words: systemic lupus erythematosus • rheumatoid arthritis • anti-ribosomal P protein antibody

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