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Review : Atherosclerosis and the antiphospholipid syndrome: A link unravelled?

Department of Medicine 'B' and the Research Unit of Autoimmune Diseases, Tel-Aviv University

D. Harats

Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

J. George

Department of Medicine 'B' and the Research Unit of Autoimmune Diseases, Tel-Aviv University

Atherosclerosis is a multifactorial disease that involves the arterial system. Recent data suggest that immune and autoimmune factors play a dominant role in mediating the progression of atherosclerosis. Among these factors, humoral response to modified forms of LDL and heat- shock proteins has been shown to be influential.

The antiphospholipid syndrome (APS) entails clinical manifestations that result from a hypercoagulable state. Antibodies to phospholipids and to β₂-glycoprotein I have been suggested to confer the tendency to thrombosis. In a set of recent studies, we have been able to show that generation of antiphospholipid antibodies in mice is associated with enhanced atherosclerosis. These findings imply that APS and atherosclerosis may share a common etiologic background, which may have direct implications for the management of both conditions.

Key Words: atherosclerosis • antiphospholipid antibodies • autoimmunity • lymphocytes • β2-glyco protein I

Lupus, Vol. 7, No. 2 suppl, S140-S143 (1998)
DOI: 10.1177/096120339800700231


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