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Lupus
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Review : Mechanism of action of β2-glycoprotein I-dependent lupus anticoagulants

J. Arnout

Center for Molecular and Vascular Biology, University of Leuven, Belgium

J. Vermylen

Center for Molecular and Vascular Biology, University of Leuven, Belgium

There is accumulating evidence showing that lupus anticoagulants (LA) are more strongly associated with thrombosis than anticardiolipin antibodies. In addition, indirect evidence has been presented indicating that β2GPI-dependent LA are more strongly associated with thrombosis than prothrombin-dependent LA. From this, one may assume that anti-β2GPI antibodies with LA activity are more pathogenic than anti-β2GPI antibodies without LA activity. Therefore, it is of the utmost importance to understand the molecular basis on which some anti-β2GPI antibodies behave as LA. In this presentation, the current knowledge on the interaction of β 2GPI with phospholipids and with anti-β2GPI antibodies is reviewed and an integrated model for the anti-β2GPI - dependent LA activity is proposed with implications for a pathogenic role of these particular antibodies.

Key Words: Beta-2-glycoprotein I • lupus anticoagulant activity • bivalent antibody interaction • affinity for phospholipid

Lupus, Vol. 7, No. 2 suppl, S23-S28 (1998)
DOI: 10.1177/096120339800700206
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