SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Lupus
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Rauch, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rauch, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Reviews

Review : Lupus anticoagulant antibodies: Recognition of phospholipid- binding protein complexes

J. Rauch

Division of Rheumatology, Department of Medicine, The Montreal General Hospital Research Institute, McGill University, Montreal, Quebec, Canada

Lupus anticoagulant antibodies form a heterogeneous group of antiphospholipid antibodies with rather poorly defined antigens. The role that phospholipid-binding proteins play in lupus anticoagulant antibody activity is a subject of current investigation. Several candidate proteins have been proposed, including β2-glycoprotein I (β2GPI), prothrombin, and annexin V. As β2GPI- dependent lupus anticoagulants will be reviewed elsewhere in this issue, this paper will focus on the involvement of prothrombin and annexin V in lupus anticoagulant activity. Evidence for a role for these proteins in the reactivity and induction of lupus anticoagulant antibodies will be discussed, as well as an apparent requirement for both phospholipid and phospholipid-binding protein. The data presented here suggest that some lupus anticoagulant antibodies recognize and may be induced by complexes of phospholipid and phospholipid-binding proteins, in particular, phospholipid and prothrombin or annexin V.

Key Words: lupus anticoagulant antibodies • phospholipids • phospholipid-binding proteins

Lupus, Vol. 7, No. 2 suppl, S29-S31 (1998)
DOI: 10.1177/096120339800700207
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 CLIN APPL THROMB HEMOSTHome page
R. L. Bick and D. Hoppensteadt
Recurrent Miscarriage Syndrome and Infertility Due to Blood Coagulation Protein/Platelet Defects: A Review and Update
Clinical and Applied Thrombosis/Hemostasis, January 1, 2005; 11(1): 1 - 13.
[Abstract] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
R. L. Bick
State-of-the-Art Review: Antiphospholipid Thrombosis Syndromes
Clinical and Applied Thrombosis/Hemostasis, October 1, 2001; 7(4): 241 - 258.
[PDF]

Home page
 LupusHome page
M Puurunen, T Palosuo, R Lassila, M Anttila, and O Vaarala
Immunologic and hematologic properties of antibodies to prothrombin and plasminogen in a mouse model
Lupus, February 1, 2001; 10(2): 108 - 115.
[Abstract] [PDF]

Home page
 LupusHome page
T P Greco, M D Amos, A M Conti-Kelly, J D Naranjo, and J W Ijdo
Testing for the antiphospholipid syndrome: importance of IgA anti-beta 2-glycoprotein I
Lupus, January 1, 2000; 9(1): 33 - 41.
[Abstract] [PDF]


Advertisement