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Review : Anti-prothrombin antibodies and their relation with thrombosis and lupus anticoagulant

Departments of Haematology and Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands

DA Horbach

Departments of Haematology and Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands

Mja Simmelink

Departments of Haematology and Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands

E. van Oort

Departments of Haematology and Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands

Rhwm Derksen

Departments of Haematology and Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands

Antiphospholipid antibodies are a heterogeneous group of antibodies, comprising antibodies with different antigen specificity. Prothrombin is one of the antigens which can be detected by antiphospholipid antibodies and therefore anti-prothrombin antibodies belong to the antiphospholipid antibody family. The presence of antiphospholipid antibodies correlates strongly with thrombo embolic complications; however a mechanism by which these autoantibodies induce a thrombotic complication in vivo is not understood. The classic assays for the detection of antiphospholipid antibodies (LAC and anticardiolipin ELISAs) aim to measure all the antiphospholipid antibodies present in the samples without making a distinction between the different subspecificities of the antibodies present in one single sample. Moreover, most of the in-vitro studies performed were carried out with total IgGs, which contain a mixture of antibodies. The absence of an accurate characterization of the plasma samples and the lack of specificity of the IgGs used in in-vitro tests makes it difficult to determine the contribution of antiprothrombin antibodies to the thrombotic complications. Here we review and critically analyse the literature regarding the clinical relevance of the presence of anti prothrombin antibodies and the possible participation of these antibodies in the pathogenesis of the thrombotic complications.

Key Words: antiprothrombin antibodies • antiphospholipid antibodies • protein C • prothrombin • lupus anticoagulant

Lupus, Vol. 7, No. 2 suppl, S32-S36 (1998)
DOI: 10.1177/096120339800700208


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